Methacrylated sodium hyaluronate is a chemically modified
hyaluronan. The methacrylate functional group is added to
the primary hydroxyl group via a reaction with methacrylic
acid anhydride under aqueous conditions. The methacrylate
group allows photo crosslinking via UV-induced
polymerization for the creation of spatially controlled
biological scaffolding and 3D bioprinting. Additional
functionality includes the chemical conjugation with
substances via thiol-ene crosslinking.
Scaffoldings created using methacrylated hyaluronic acid
have a wide range of physical properties depending on the
degree of substitution (DOS) percentage of the methacrylate
functional group, the molecular weight of the hyaluronic
acid, and the concentration of the methacrylated hyaluronic
acid solution. Lifecore’s reaction control processes,
techniques, and technologies allow us to create
methacrylated hyaluronic acid with tailored and
customizable DOS to fit your specific research and
development needs.
Methacrylated sodium hyaluronate’s functionality is executable under
physiologic conditions, allowing for the direct inclusion of cells or bioactive
agents after photo polymerization or thiol-ene conjugation. Much of the
native sodium hyaluronate structure and behavior can be maintained
allowing your crosslinked structures to maintain cell and tissue viability.
With a fully customizable DOS and molecular weight package, Lifecore may
provide any form of methacrylated hyaluronic acid to meet your project
goals. Our internal quality systems and CDMO process development team
allow us to internally scale your project towards a GMP-ready state once your
specific, desired properties have been adequately researched and
developed. Off the shelf, research-grade methacrylic hyaluronic acid
offerings at various degrees of substitutions are listed below to get your
project’s research started. Please contact us for customized
methacrylated sodium hyaluronate.
The ranges listed are for cataloging purposes only. A discrete average molecular weight is reported on the Certificate of Test that accompanies product.
Shipping is not included in pricing. All shipments are FedEx Priority Overnight (standard) or FedEx 2-Day (in certain geographies) unless purchaser selects their own carrier. Shipping cost does not include any customs fees or import duties.
Orders ship in an insulated shipper with ice packs.
US$25 handling will be added to each order.
Additional credit card and wire transfer fees may apply.
The ranges listed are for cataloging purposes only. A discrete average molecular weight is reported on the Certificate of Test that accompanies product.
Shipping is not included in pricing. All shipments are FedEx Priority Overnight (standard) or FedEx 2-Day (in certain geographies) unless purchaser selects their own carrier.
Shipping cost does not include any customs fees or import duties.
Orders ship in an insulated shipper with ice packs.
US$25 handling will be added to each order.
Additional credit card and wire transfer fees may apply.
The ranges listed are for cataloging purposes only. A discrete average molecular weight is reported on the Certificate of Test that accompanies product.
Shipping is not included in pricing. All shipments are FedEx Priority Overnight (standard) or FedEx 2-Day (in certain geographies) unless purchaser selects their own carrier. Shipping cost does not include any customs fees or import duties.
Orders ship in an insulated shipper with ice packs.
US$25 handling will be added to each order.
Additional credit card and wire transfer fees may apply.
